African Americans continue to be disproportionately affected by the HIV/AIDS epidemic. According to the Centers for Disease Control (CDC), Blacks/African Americans account for a higher proportion of new HIV diagnoses, those living with HIV, and those ever diagnosed with AIDS, compared to other races/ethnicities. In 2015, African Americans accounted for 45% of HIV diagnoses, though they comprise 12% of the US population. In 2015, almost half (48%) of those diagnosed with AIDS in the United States were African American. In 2014, African Americans accounted for more than half (53%) of the deaths attributed to HIV/AIDS. Among all women with HIV diagnosed in 2015, 61% were African American, 19% were White, and 15% were Hispanic/Latina.

According to the Indiana State Department of Health, by the end of 2017, a total of 12,635 persons were living with HIV/AIDS in Indiana. Most people living with HIV/AIDS in Indiana are concentrated in the urban areas of the state, however rural areas are also affected. The majority live in Central Indiana and the Indianapolis Metropolitan area. In 2017, the breakdown by race/ethnicity for those newly diagnosed with HIV/AIDS were: Black Р46.6%, White Р37.7%, Hispanic Р13.8%, Other Р4.9%.